2025-01-15T16:43:03+00:00 2023-12-31 440160260 Forvis Mazars LLP 500 Ridgefield Court Asheville NC 28806 990 2023-01-01 830671720 Hope For Annabel Inc HOPE 8778295500 1600 Parkwood Circle 200 Atlanta GA 30339 Nina Frost President 2025-01-15 true true Amy Bibby P00445891 8282542254 2025-01-15 2023 2024-10-15 13:58:12Z Nina Frost 1600 Parkwood Circle 200 Atlanta GA 30339 8392 false X WWW.HOPEFORANNABEL.ORG X 2018 GA The MISSION of the HOPE FOR ANNABEL FOUNDATION is the execution of a targeted plan to use gene therapy to cure AHC, and to help develop treatment protocols for other rare diseases. 7 7 0 0 0 0 231023 8392 0 0 0 0 0 0 231023 8392 0 0 0 0 0 0 0 0 0 68279 203099 68279 203099 162744 -194707 702046 507100 239 0 701807 507100 X The MISSION of the HOPE FOR ANNABEL FOUNDATION is the execution of a targeted plan to use gene therapy to cure AHC, and to help develop treatment protocols for other rare diseases. false false 79012 Northwestern: 2 grants. One funded work to evaluate the effects of an ATP1A3 transgene on patient derived iPSC neurons, an in vitro investigation of gene therapy. The second evaluated antisense oligonucleotides as a suitable therapeutic modality for AHC. 20167 Massachusetts General Hospital: This grant supported the purchase of an advanced microscope for Dr. Kathleen Sweadner's lab. This lab investigates protein trafficking and morphology in AHC cellular models: these are altered in AHC but can be rescued with therapies, potentially including genetic therapies. 20000 Leavitt Partners: This payment was made to found the Genomic Answers for Children's Health Alliance (GACHA). The GACHA charter calls for the centralization and systemization of whole genome sequencing data to accommodate a scaled approach to rare disease R&D. The objective is to provide expanded access to genetic therapies to all patients. 83920 Other Gene Therapy Expenditures to Further Organization's Mission 83920 203099 true false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false false true 0 0 0 false false false false false false false false X 7 7 true false false false false false false true true false false false true true true true true false false false GA X Simon Frost 2026808653 400 N FLAGLER - PHB2 West Palm Beach FL 33401 Nina Frost President and Secretary 10.0 X X 0 0 0 Simon Frost CEO and Treasurer 10.0 X X 0 0 0 Carola Mamberto Director 1.0 X 0 0 0 James Reyes Director 1.0 X 0 0 0 Jennifer Fuisz Director 1.0 X 0 0 0 Lisa Garnett Director 1.0 X 0 0 0 Thomas Cohen Director 1.0 X 0 0 0 0 0 0 0 false false false 0 8392 8392 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8392 0 0 0 0 0 0 0 RESEARCH FUNDING 203099 203099 0 0 0 0 203099 203099 0 0 702046 507100 0 0 0 0 0 0 0 0 0 0 702046 507100 239 0 0 0 239 0 701807 507100 701807 507100 702046 507100 -194707 0 X false false false X 565865 125842 13795 231023 8392 944917 0 0 565865 125842 13795 231023 8392 944917 466252 478665 0 0 0 0 0 0 0 0 944917 0 0.5066 X Form 990, Part III, Line 4d Description of other program services (Expenses $ 83,920 including grants of $) Other Gene Therapy Expenditures to Further Organization's Mission Form 990, Part VI, Line 2 Family/business relationships amongst interested persons Nina Frost and Simon Frost - Family relationship Form 990, Part VI, Line 11b Review of form 990 by governing body The treasurer, President, and Secretary review and approve 990 based on the financial statements. Form 990, Part VI, Line 12c Conflict of interest policy All persons are required to disclose in writing any conflict of interest or potential conflict of interest. Each year each person must confirm they have not engaged in any conflict of interest transaction. The officers and the board separately monitors all transactions to consider potential conflict of interest. After disclosure of a potential conflict of interest the independent members of the board vote upon whether a conflict exists. Any conflict of interest violation is addressed in the manner set forth in the conflict of interest policy. A copy of the policy is available upon request. Form 990, Part VI, Line 19 Required documents available to the public Upon request