2025-11-03T13:36:36-08:00 2024-12-31 113344284 Piccirillo Lamont & Giammarese LLP 181 W Main Street Suite 101 Babylon NY 11702 990PF 2024-01-01 200284800 THE JAIN FOUNDATION INC JAIN 4258821492 9706 4TH AVENUE NE 101 SEATTLE WA 98115 LAURA RUFIBACH CO-PRESIDENT 2025-11-03 true true CAROL A ZOELLER CPA P01454472 6313762300 2024 2025-03-06 01:10:19Z X 93069116 X X 384162 384162 384162 384162 616567 63301 553265 502337 502337 33940 33940 12800 12800 44000 44000 15000 105748 105748 240974 240974 1177 1177 379425 379425 1951968 63301 1873666 3436865 3436865 5388833 63301 5310531 -5004671 320861 66782 505733 505733 7500000 2090466 2090466 81250 79177 79177 48506460 48506460 90392330 1410 1410 1410 56155902 51183246 93069116 36153 68168 36153 68168 X 56119749 51115078 56119749 51115078 56155902 51183246 56119749 -5004671 51115078 51115078 4460 4460 4460 10133 5000 15133 X 10673 10673 false false false false false false false true true NY true false false false false true JAIN-FOUNDATION.ORG LAURA RUFIBACH 4258821492 9706 4TH AVENUE SUITE 101 SEATTLE WA 98115 false false false false false false false false false false false false false false false false false false false false false false AJIT JAIN ISLAND DRIVE RYE NY 10580 Director 3.00 0 INDRIMA JAIN ISLAND DRIVE RYE NY 10580 Director 1.00 0 ASHKAY JAIN ISLAND DRIVE RYE NY 10580 CEO 40.00 211003 DOUG ALBRECHT PHD 9706 4TH AVE NE STE 101 SEATTLE WA 89115 CO-PRESIDENT 40.00 202782 LAURA RUFIBACH 9706 4TH AVE NE STE 101 SEATTLE WA 89115 CO-PRESIDENT 40.00 202782 SARAH S EMMONS 2127 33RD AVE W SEATTLE WA 98199 DIR. PATIENT 40.00 160500 LAURIE R LONG 9513 EVANSTON AVE N SEATTLE WA 98103 OFFICE MGMT 40.00 74293 BRADLEY A WILLIAMS 12034 15TH AVE NE 104 SEATTLE WA 98125 DIR. RESEARCH 40.00 114378 KANAN LATHIA 7620 NE 32ND ST MEDINA WA 98039 ASSOC DIR RESEARCH 40.00 90000 MAGGIE CURTIS 9706 4TH AVE NE SUITE 101 SEATTLE WA 98115 PROGRAM COORDINATO 40.00 60000 NONE While the focus of the Jain Foundation is Dysferlinopathy (LGMD2B/R2/Miyoshi Myopathy1), the resulting scientific advances and collaborations that we make have a broader impact on human health through their relevance to other muscle disorders, degenerative diseases, and normal aging. The Foundation takes a hands-on approach to funding. We closely monitor the progress of every project we fund and keep track of results and shifting timelines through quarterly conference calls with researchers and site visits. We also support internal programs and initiatives. Our goal is to fund all possible approaches to a cure and help with patient diagnosis to ensure that treatments reach those who need them. 0 Clinical Trial readiness and Community Engagement ($246,298): Dysferlinopathy is very rare. An important goal of the Jain Foundation is to prepare the dysferlinopathy patient community for clinical trials. There are many aspects to being clinical trial ready, including patient identification, community engagement, patient education, and identification of outcome measures. For patient identification we have a patient registry called the Dysferlin Registry that contains 1200+ individuals verified to have dysferlinopathy. In addition, we have a diagnosis pipeline that provides access to genetic testing for those who need it and ensures that barriers to genetic testing dont prevent people with dysferlinopathy from accessing the Dysferlin Registry. In 2024, we added ~ 80+ dysferlinopathy patients to the registry. Community engagement and education includes interactions with the patient community, clinicians, LGMD advocacy groups, Industry and the FDA. Our patient education and engagement ef 246298 Tools for Researchers ($257,622): As a recognized leader in the field, we continue to receive queries and help researchers access reagents such as antibodies and cell lines that are required for their research. In addition, we actively identify and fund the development of research tools and resources needed to advance the dysferlin field. The Jain Foundation is committed to developing and providing frequently required reagents, the availability of which helps accelerate research. We contributed dysferlin DNA to public repositories and have helped companies develop antibodies to dysferlin so that they can be easily obtained. We built a library of cell lines that are useful to study dysferlin deficiency. In 2024, we continued to maintain large colonies of mice at the custom mouse breeding facility at Jackson Laboratories (USA) and Ozgene ARC (Australia) for use in dysferlin research. Information about these resources is disseminated to researchers through e-mails and through the Foundati 257622 Dysferlin Conference ($275,104): The 2025 Dysferlin Conference brought together over 100 scientists, clinicians, industry leaders, advocacy, and patients working to understand and develop a therapy for Dysferlinopathy. The objective of the 2025 Dysferlin Conference, that was held May 8-11, 2024 in Houston, TX, was to speed research on dysferlinopathy through the sharing of ideas and research results on dysferlinopathy. By promoting the sharing of ideas and unpublished data between scientists actively working on dysferlin, scientists can rapidly improve the focus of their research to the most relevant and therapy-oriented areas. During this meeting, all those in attendance gained a deeper understanding of the mechanism of the disease and learned about the progress in testing therapies from the 40+ talks and 24 posters. The conference was sponsored and organized solely by the Jain Foundation 275104 85576523 5332312 0 90908835 0 90908835 1363633 89545202 4477260 4477260 4460 4460 4472800 4472800 4472800 5310531 5310531 4472800 1654250 1594562 1659525 1628423 2139899 8676659 5310531 0 4472800 837731 9514390 0 1654250 7860140 1594562 1659525 1628423 2139899 837731 LAURA RUFIBACH 9706 4TH AVE NE STE 101 SEATTLE WA 98115 4258821492 LRUFIBACH@JAIN-FOUNDATION.ORG SEE FOUNDATION WEBSITE JAIN-FOUNDATION.ORG THERE ARE NO SUBMISSION DEADLINES. THE EXPLICIT GOAL OF THE JAIN FOUNDATION IS TO EXPEDITE DEVELOPMENT OF A TREATMENT OR CURE FOR LGMD2B/MIYOSHI. ANY PROPOSED PROJECT THAT DOES NOT HAVE APPLICATION TO THIS DISEASE WILL NOT BE CONSIDERED. 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