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        <FormAndLineReferenceDesc>Schedule D, Part X, Line 2 FIN 48 (ASC 740) footnote</FormAndLineReferenceDesc>
        <ExplanationTxt>The Organization qualifies under Section 501(c)(3) of the Internal Revenue Code and is, therefore, generally not subject to income taxation under present income tax laws. However, the Organization is subject to federal tax on any unrelated business taxable income. The Organization accounts for uncertainty in income taxes using the provisions of Accounting Standards Codification (ASC) 740, Income Taxes. Using that guidance, tax positions initially need to be recognized in the consolidated financial statements when it is more-likely-than-not the positions will be sustained upon examination by the tax authorities. A recognized tax position is measured at the largest amount of benefit that has a greater than 50% likelihood of being realized upon settlement. It also provides guidance for derecognition, classification, interest and penalties, accounting in interim periods, disclosure, and transition. The Organization recognizes interest and/or penalties related to income tax matters in income tax expense and did not have any amount accrued for interest and penalties at December 31, 2024. The Organization files informational returns with the U.S. federal government. The Organization is no longer subject to U.S. federal tax examinations for years prior to 2021.</ExplanationTxt>
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        <ExplanationTxt>EUROPE (INCLUDING ICELAND AND GREENLAND)-Accrual</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part III, Line 2 New program services</FormAndLineReferenceDesc>
        <ExplanationTxt>Program service areas were re-organized for 2024 to better reflect the maturing and expansion of the organization. Program service areas include: Leadership &amp; Collaboration, Service Delivery, Medicines &amp; Diagnostics, Data &amp; Research, Financing &amp; Policy.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part III, Line 4d Description of other program services</FormAndLineReferenceDesc>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Line 7a Members or stockholders electing members of governing body</FormAndLineReferenceDesc>
        <ExplanationTxt>Potential board members are nominated by an existing board member. Elections are conducted by a vote of the Board, and the approval of a majority of Directors present at a meeting where a quorum is established constitutes an official act of the Board.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Line 8b Documentation of meetings held by committees of governing body</FormAndLineReferenceDesc>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Line 11b Review of form 990 by governing body</FormAndLineReferenceDesc>
        <ExplanationTxt>A copy of the Form 990 is provided to the board via email for review prior to filing with the IRS.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Line 12c Conflict of interest policy</FormAndLineReferenceDesc>
        <ExplanationTxt>Each Board Member, consultant, volunteer, and employee is asked to sign an annual conflict of interest disclosure form to affirm compliance with the COI policy.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Line 15a Process to establish compensation of top management official</FormAndLineReferenceDesc>
        <ExplanationTxt>Compensation for officers and employees is reviewed annually by the Board of Directors. This review is informed by an evaluation conducted by the Executive Director, which considers standard compensation for similar positions in the United States.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Line 19 Required documents available to the public</FormAndLineReferenceDesc>
        <ExplanationTxt>The organization makes its governing documents, conflict of interest policy and financial statements available to the public upon request.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part IX, Line 11g Other Fees</FormAndLineReferenceDesc>
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