2025-11-17T12:16:15-06:00 2023-06-30 810446334 DOUGLAS WILSON & COMPANY PC 1000 FIRST AVENUE SOUTH GREAT FALLS MT 59401 990 2022-07-01 810459235 MCLAUGHLIN RESEARCH INSTITUTE FOR BIOMEDICAL SCIENCES INC MCLA 4064546015 1520 23RD STREET SOUTH GREAT FALLS MT 59405 RENEE REIJO PERA PRESIDENT 4064546015 2025-11-17 1 1 GERARD K SCHMITZ P00039906 4067614645 2022 2025-03-06 01:10:19Z RENEE REIJO PERA 1520 23RD STREET SOUTH GREAT FALLS MT 59405 3893028 0 X WWW.MCLAUGHLINRESEARCH.ORG X 1989 MT THE INSTITUTE'S MISSION IS TO IMPROVE HUMAN HEALTH THROUGH INNOVATIVE GENETIC RESEARCH AND EDUCATION. 12 11 37 0 0 0 5434274 1912216 1865331 435360 334242 64808 2921 2951 7636768 2415335 6500 48750 0 0 2202780 2704683 0 0 231343 1489332 1537428 3698612 4290861 3938156 -1875526 15630159 14106801 340002 243063 15290157 13863738 X THE INSTITUTE'S MISSION IS TO IMPROVE HUMAN HEALTH THROUGH INNOVATIVE GENETIC RESEARCH AND EDUCATION. RESEARCH AT THE INSTITUTE FOCUSES ON UNDERSTANDING THE GENETIC CONTROL OF NORMAL DEVELOPMENT AND SUSCEPTIBILITY TO NEUROLOGICAL DISEASES USING THE MOUSE AS THE MODEL SYSTEM. THE INSTITUTE ALSO OFFERS RESEARCH INTERNSHIPS FOR STUDENTS AND TEACHERS. 0 0 3744086 438311 DURING FISCAL YEAR 2023, THE INSTITUTE SCIENTISTS AND STAFF CONTINUED THEIR EFFORTS TO BETTER UNDERSTANDING THE CELLULAR AND MOLECULAR MECHANISMS OF NEURODEGENERATIVE DISEASE PROCESSES THROUGH INNOVATIVE GENETIC APPROACHES IN MURINE MODELS WHILE EXPANDING THE PROGRAM OF TRANSLATIONAL RESEARCH TO SUPPLEMENT TREATMENT ADVANCES AND EDUCATION THROUGH COMMUNITY ENGAGEMENT WITH STUDENT INTERNSHIPS. WITH CONTRIBUTIONS RECEIVED THE PREVIOUS YEAR, THE INSTITUTE WAS ABLE TO HIRE TWO ADDITIONAL SCIENTISTS. EXPANDED SCIENTIFIC EMPLOYMENT LED TO EXPANDED RESEARCH TO INCLUDE SUBJECTS OF HUMAN PRIMORDIAL GERM CELLS, MACULAR DEGENERATION, NEUTROPHILS IN AGE RELATED DISEASES, AND NOVEL ASSAY OPTIMIZATION FOR THE IMPROVED DIAGNOSTICS OF NEURODEGENERATIVE DISEASES. FURTHER RESEARCH ON THE EMPHASIS OF GENETIC SUSCEPTIBILITY; CELLULAR MECHANISM COMPONENTS OF PROTEIN MISFOLDING PROPAGATION; IDENTIFICATION OF BIOMARKERS; THE ROLE OF MICROBIOME AND INFLAMMATION; AND CELLULAR SENESCENCE IN DISEASES SUCH AS FRONTOTEMPORAL DEMENTIA, ALZHEIMER'S AND PRION DISEASES, AS WELL AS NOVEL TREATMENT APPROACHES. SUCH WORK INCLUDED PARTNERSHIPS WITH UP TO TEN COLLABORATORS AND 24 PROJECTS AMONG INVESTIGATORS WITH PARTNERSHIPS EXTENDING NATIONALLY TO NEW YORK, MASSACHUSETTS, NORTH CAROLINA, WASHINGTON STATE AND CALIFORNIA WHICH RESULTANT SUBAWARDS CONTRIBUTED TO $413,000 OF NIH GRANT FUND SUPPORT AND $430,000 IN RESEARCH CONTRACTS. EFFORTS CONTINUED TOWARDS UNDERSTANDING HUNTINGTON'S DISEASE IN COLLABORATION WITH INVESTIGATORS FROM WESTERN WASHINGTON UNIVERSITY AND THE CURE HUNTINGTON'S DISEASE FOUNDATION; ALZHEIMER'S DISEASE WITH PARTNERS AT COLUMBIA UNIVERSITY AND WAKE FOREST UNIVERSITY; AS WELL AS MAKING STRIDES ON INVESTIGATOR LED STUDIES AND FUTURE FUNDING OPPORTUNITIES WITH THE NATIONAL INSTITUTES OF HEALTH. INVESTIGATORS CONTINUED CRITICAL WORK WITH NEW TREATMENT DEVELOPMENT SCREENING THROUGH ONGOING COLLABORATION WITH PHARMACEUTICAL COMPANIES AND WELCOMED NEW COLLABORATIONS WITH CUREDRPLA AND N-LOREM. THE INSTITUTE CONTINUED THE EFFORTS OF THE NIH FUNDED GRANT (AWARDED MARCH 2018) IN THE AMOUNT OF $405,000/YEAR FOR FIVE YEARS DIRECTED TOWARDS BETTER UNDERSTANDING OF ELECTROPHYSIOLOGY OF NEUROTRANSMITTERS IN NEURODEGENERATIVE DISEASES WITH THE FINAL YEAR IN COMPLETED ON A NO COST EXTENSION. NIH AWARD OF $360,306 WAS RECEIVED FOR DISSECTION OF THE TRANSCRIPTIONAL NETWORKS OF HUMAN PRIMORDIAL GERM CELLS AND $292,000 FOR AGE RELATED MACULAR DEGENERATION RESEARCH. THE INSTITUTE RECEIVED $457,000 IN CONTRIBUTIONS THAT WAS USED TO SUPPORT INVESTMENTS FOR FUTURE RESEARCH AND EDUCATION. 48750 48750 THE INSTITUTE CONTINUED THE SUMMER INTERNSHIP PROGRAM WITH HOSTING AN ASTOUNDING 18 HIGH SCHOOL AND COLLEGE INTERNS. A TOTAL OF $48,750 WAS AWARDED TO THE PARTICIPATING INTERNS WHO COMPLETED THE 8-WEEK SUMMER PROGRAM AND ROTATING BETWEEN EACH LAB WITH ONE COLLEGE INTERN CONTINUING WITH AN EXTENDED PROGRAM THAT INCLUDED MACHINE LEARNING DATA ANALYSIS AND RESULTED IN SCIENTIFIC PUBLICATION. FURTHER EDUCATION EFFORTS EXTENDED TO THE TOURO COLLEGE OF OSTEOPATHIC MEDICINE-MONTANA WITH INVESTIGATORS GAINING PROFESSORSHIP APPOINTMENTS AT THE NEW MEDICAL SCHOOL. 3792836 1 1 0 1 0 0 0 0 0 1 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 14 0 1 37 1 0 0 0 0 0 0 0 0 0 0 X 12 11 1 0 0 0 0 0 0 1 1 0 0 0 1 1 1 1 1 1 0 0 X X X THE ORGANIZATION 4064546015 1520 23RD STREET SOUTH GREAT FALLS MT 59405 RANDY GRAY CHAIR 5.00 X X 0 0 0 MAXON DAVIS VICE-PRESIDENT 1.00 X X 0 0 0 BJARNE JOHNSON SECRETARY 1.00 X X 0 0 0 GARY BJELLAND BOARD MEMBER 1.00 X 0 0 0 DAVID CAMERON PHD BOARD MEMBER 1.00 X 0 0 0 GEORGE A CARLSON PHD BOARD MEMBER 1.00 X 0 0 0 PAUL EICHWALD BOARD MEMBER 1.00 X 0 0 0 JOHN LANE BOARD MEMBER 1.00 X 0 0 0 ERIK SLETTEN BOARD MEMBER 1.00 X 0 0 0 CATHIE TRONSON BOARD MEMBER 1.00 X 0 0 0 DR IRVING WEISSMAN BOARD MEMBER 1.00 X 0 0 0 ARLYNE REICHERT HONORARY BOARD MEMBER 1.00 X 0 0 0 GENE THAYER EXECUTIVE BOARD CHAIR 1.00 X 0 0 0 RENEE REIJO PERA DIRECTOR/CURRENT PRESIDENT 40.00 X X 222357 0 36392 MEGANNE CASEY CURRENT VP OPERATIONS 40.00 X 105032 0 10500 DEBORAH CABIN CURRENT VICE PRESIDENT 40.00 X 119701 0 19900 TERESA GUNN ASSOCIATE PROFESSOR 40.00 X 120750 0 20017 567840 0 86809 4 0 1 0 0 1439987 472229 1912216 CONTRACT RESEARCH 541700 435360 435360 435360 214279 214279 1328222 1477693 -149471 -149471 -149471 MISCELLANEOUS 541900 2951 2951 2951 2415335 438311 0 64808 48750 48750 606313 284079 263821 58413 1503296 1078781 340898 83617 198175 126386 57586 14203 229410 157089 53257 19064 167489 109556 47881 10052 4928 4928 297 297 76682 76682 47659 8775 21243 17641 7376 46 7330 25053 23769 1284 33355 28963 4392 267339 267339 17336 12918 327 4091 8329 5029 3300 1836 1836 401473 1260 400213 46718 46718 LAB SUPPLIES AND SERVIC 227978 227978 ANIMAL CARE SERVICES 123701 123701 REPAIRS AND MAINTENANCE 63758 9956 53802 REPAIRS AND MAINTENANCE 38049 38049 145561 1598578 -1464273 11256 4290861 3792836 266682 231343 660993 192980 22035 20846 814319 826127 113805 180354 16636174 10724447 5984520 5911727 6544067 6864980 1486108 105475 4312 4312 15630159 14106801 67372 33918 55292 25260 24607 0 192731 183885 340002 243063 X 11576169 10497153 3713988 3366585 15290157 13863738 15630159 14106801 X -1875526 456857 -2121 -5629 X 0 1 X 0 1 1 X 1152431 1883327 2539350 5434274 1912216 12921598 1152431 1883327 2539350 5434274 1912216 12921598 6067273 6854325 346714 497796 451110 240398 214279 1750297 2197 4323 4684 2921 2951 17076 14688971 0.46660 0.41460 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 0 3775867 3775867 338793 84698 0 0 159659 258511 311512 338793 1068475 1602713 39915 64628 77878 84698 267119 400679 3420068 20569 343750 3096887 3780826 42551 403309 3420068 3259494 553555 32223 3780826 3522643 990 -89345 174794 3259494 3532486 465489 475332 3522643 1 0 25000 25000 11295806 6262658 5033148 4584004 3877767 706237 731364 584022 147342 5911727 ANNUITY OBLIGATIONS 183885 183885 PART V, LINE 4: EARNINGS OF THE INSTITUTE'S ENDOWMENT FUNDS ARE USED TO SUPPORT GENERAL AND SPECIFIC RESEARCH AND EDUCATIONAL PROGRAMS. PART XI, LINE 2D - OTHER ADJUSTMENTS: CHANGE IN SPLIT-INTEREST AGREEMENT 0 STUDENT INTERNSHIP PROGRAM 18 48750 EDUCATIONAL ACTIVITIES ARE CONDUCTED AT THE INSTITUTE ITSELF, WITH STUDENTS AND TEACHERS BEING MENTORED BY FACULTY AND STAFF DURING HANDS-ON RESEARCH INTERNSHIPS. 0 0 0 0 0 0 0 0 0 RENEE REIJO PERA DIRECTOR/CURRENT PRESIDENT 222357 0 0 0 0 0 22525 0 13867 0 258749 0 0 0 FORM 990, PART VI, SECTION A, LINE 2 MANY MEMBERS OF THE INSTITUTE'S BOARD OF DIRECTORS ARE PROMINENT MEMBERS OF THE BUSINESS COMMUNITY AND INCLUDE ATTORNEYS, ACCOUNTANTS, GENERAL CONTRACTORS, DOCTORS AND RETAILERS WHO PROVIDE SERVICES AND PRODUCTS ON AN ARMS-LENGTH BASIS TO THE COMMUNITY AND SURROUNDING TRADE AREA INCLUDING OTHER MEMBERS OF THE INSTITUTE'S BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 11B THE FORM 990 IS PREPARED BY AN OUTSIDE ACCOUNTING FIRM WITH ADDITIONAL REVIEW BY THE ORGANIZATION'S FINANCE OFFICER BEFORE SUBMISSION. FORM 990, PART VI, SECTION B, LINE 12C BOARD MEMBERS ARE REQUIRED TO COMPLETE A CONFLICT OF INTEREST QUESTIONNAIRE ON AN ANNUAL BASIS. INSTITUTE ACTIVITIES ARE VERY SPECIALIZED WITH A RELATIVELY SMALL NUMBER OF SUPPLIERS. THE FINANCIAL OFFICER IS RESPONSIBLE FOR MONITORING TRANSACTIONS WITH PARTIES RELATED TO BOARD MEMBERS. THE INSTITUTE MAINTAINS A SEPARATE CONFLICT OF INTEREST POLICY FOR ITS RESEARCH STAFF TO ENSURE COMPLIANCE WITH FEDERAL REGULATIONS REGARDING DISCLOSURE OF CONFLICTS. FORM 990, PART VI, SECTION B, LINE 15A THE INSTITUTE'S BOARD OF DIRECTORS AND SCIENTIFIC ADVISORY COMMITTEE REVIEW AND APPROVE COMPENSATION PAID TO THE INSTITUTE'S DIRECTOR/PRESIDENT. AMONG OTHER THINGS, THE BOARD REVIEWS COMPENSATION SURVEYS CONDUCTED BY THE ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES. ADDITIONALLY, SALARY RESTRICTIONS ARE PLACED ON THE CHIEF SCIENTIST BY NATIONAL INSTITUTES OF HEALTH GUIDELINES. THE DIRECTOR'S SALARY IS WELL WITHIN THE ABOVE PARAMETERS AND HAS BEEN INCREASED SINCE JULY 2014. ALL INSTITUTE SALARIES ARE DISCUSSED AND REVIEWED BY THE FINANCE COMMITTEE AS PART OF ITS ANNUAL BUDGET REVIEW PROCESS. FORM 990, PART VI, SECTION C, LINE 19 THE INSTITUTE'S AUDITED FINANCIAL STATEMENTS, FORM 990, AND CONFLICT OF INTEREST POLICY ARE POSTED AND AVAILABLE ON THE INSTITUTE'S WEBSITE (MCLAUGHLINRESEARCH.ORG). FINANCIAL STATEMENTS AND TAX FORMS ARE ALSO POSTED AND AVAILABLE ON THE WEBSITES OF VARIOUS NONPROFIT INFORMATION SERVICES. FORM 990, PART XI, LINE 9: CHANGE IN VALUE OF SPLIT INTEREST AGREEMENTS -5,629. LEWIS AND CLARK BIOLOGICALS INC 1520 23RD STREET S GREAT FALLS MT 59405 810460863 SALES - MISCELLANEOUS MT MCLAUGHLIN RESEARCH C 1.00000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0