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      <Desc>ResearchClinical Research Type 1 Diabetes:Sansum Diabetes Research Institute (SDRI) is a global leader in advancing research, education, and clinical care for people impacted by type 1 diabetes (T1D). SDRI is a preferred site for clinical trials, a testament to our exceptional research capabilities and unwavering commitment to improving diabetes care. In 2024 alone, SDRI conducted 18 clinical research trials and engaged more than 600 participants. Current industry partners include Abbott Diabetes Care, Dexcom, Insulet, Eli Lilly, MannKind, Medtronic Diabetes, Sanofi, and others.As a trusted industry partner, SDRI is committed to conducting pivotal studies that evaluate the accuracy and efficacy of diabetes management technologies, such as continuous glucose monitors and insulin pumps. These innovations have transformed T1D care by enabling real-time adjustments and easing the mental burden of daily management. SDRI remains dedicated to collaborating with industry leaders to improve the quality of life for those living with diabetes.Through cutting-edge research, education, and advocacy, SDRI continues to advance diabetes care. In 2024, SDRI conducted two clinical trials involving 41 pediatric participants with T1D, contributed to research on continuous ketone monitors (CKMs) to help detect ketone level changes and prevent diabetic ketoacidosis (DKA), and participated in a multicenter randomized clinical trial evaluating inhaled insulin plus basal insulin as a potential new treatment strategy.Whether through technology-driven solutions, innovative community programs, or groundbreaking clinical trials, SDRI continues to lead in diabetes research, delivering meaningful insights that enhance the lives of people with T1D.Clinical Research Type 2 Diabetes:SDRI is committed to groundbreaking research aimed at discovering new ways to manage type 2 diabetes (T2D), one of the fastest-growing chronic diseases worldwide. We recognize that education is essential to effective diabetes management, and our team takes a holistic approach, with a special focus on expanding access to education and research opportunities in underserved communities.In 2024, SDRI was one of only 21 U.S. sites selected to conduct a clinical trial using the Omnipod 5 Automated Insulin Delivery (AID) System in adults with T2D. This landmark study demonstrated that the Omnipod 5 significantly reduced HbA1c levels in a socioeconomically, racially, and ethnically diverse population. Participants also reported improvements in time in range, sleep quality, diabetes-related distress, and confidence in preventing hypoglycemia, highlighting the potential of this technology to transform T2D care. SDRI is proud to be at the forefront of efforts to improve diabetes outcomes through innovation and inclusion.In a related area of research, SDRI also evaluated a new treatment strategy in 2024: combining inhaled insulin with basal insulin to reduce post-meal glucose spikes. While this study focused on individuals with T1D, the findings may inform future T2D interventions as well.</Desc>
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        <Desc>Education and Community OutreachIn addition to clinical research, SDRI is deeply committed to diabetes education and health equity. Since 2008, the Ocho Pasos program has addressed the high prevalence of type 2 diabetes (T2D) in the Latino community, where cultural, linguistic, and systemic barriers often limit access to care. SDRI-trained Community Health Workers (CHWs), who are trusted leaders within their communities, lead participants through an eight-week, Spanish-language course focused on culturally relevant education around nutrition, physical activity, and diabetes self-management.Nationally recognized for its success, Ocho Pasos has demonstrated measurable improvements in participants waist circumference, BMI, and glycemic control, even among individuals facing challenges such as food insecurity and limited access to healthcare. SDRI is proud to sustain and expand this impactful program, ensuring that underserved communities are equipped with the tools they need for lasting health.SDRIs type 1 diabetes (T1D) program continues to deliver essential research and community support to individuals and families affected by T1D. In 2024, SDRI launched LADATalk, a monthly support group for individuals living with Latent Autoimmune Diabetes in Adults (LADA). This welcoming space offers connection, shared experiences, and expert insight tailored to this unique form of diabetes.Beyond LADA, SDRI reinforced its support for the broader T1D community through initiatives such as the OneTalk peer support program, family outreach events, research presentations, and a continued partnership with the American Diabetes Association (ADA) and Breakthrough T1D on the 5th annual Returning to School with Diabetes Town Hall. The event featured a diverse panel of experts in diabetes and mental health, offering vital guidance to families navigating school life with diabetes.</Desc>
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        <Desc>Clinical CareSDRI provides expert clinical care across three key areas: diabetes in pregnancy, pediatric endocrinology, and adult endocrinology. In 2024, SDRI supported more than 250 individuals impacted by diabetes, including 93 adults, 22 children, and 143 women with pregnancies complicated by diabetes. Also in 2024, SDRI expanded services and introduced counseling services to support the emotional well-being of our patients.For nearly 50 years, SDRI has been a recognized leader in managing diabetes during pregnancy. Our team is dedicated to advancing research that reduces the risks associated with diabetes in pregnancy. During appointments, patients receive personalized care and innovative tools to help stabilize blood glucose levels, limiting complications for both mother and baby.SDRI proudly partners with the Santa Barbara County Public Health Department to ensure that underrepresented Latina women receive high-quality, culturally competent care throughout pregnancies affected by diabetes.Recognizing that diabetes affects individuals differently, SDRI is committed to understanding sex-specific differences in disease progression and treatment response. Women living with diabetes face increased health risks, including a higher likelihood of cardiovascular complications, gestational diabetes, and an association between early menopause and type 2 diabetes.In 2024, SDRI launched three pioneering clinical trials focused on continuous glucose monitoring and lifestyle interventions for diabetes in pregnancy. SDRI remains at the forefront of advancing care that improves both the health span and lifespan of women and their babies during and after pregnancy.To improve accessibility of mental health services for those impacted by diabetes locally, SDRI began providing counseling support in 2024 for patients allowing them the opportunity to meet with a licensed therapist. Additionally, SDRI provides three monthly support groups for those impacted diabetes and various outreach events for individuals and families.</Desc>
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        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Elena F Engel</PersonNm>
        <TitleTxt>Secretary</TitleTxt>
        <AverageHoursPerWeekRt>2.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <OfficerInd>X</OfficerInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Joan Arnold</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Miguel Avila</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Daniel Berger MD</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Anthony Castillo</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Daren Dickerson</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Lindsey Duca</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Lynn Fitzgibbons MD</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Yvette Giller</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Steven Jung Esq</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Norman A Kurland</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Robert Nagy MD</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Michael J Paskin</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Wendy Thies Sell</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>4.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>Mark Wilson MD</PersonNm>
        <TitleTxt>Trustee</TitleTxt>
        <AverageHoursPerWeekRt>1.00</AverageHoursPerWeekRt>
        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <TotalReportableCompFromOrgAmt>1673799</TotalReportableCompFromOrgAmt>
      <TotalOtherCompensationAmt>168491</TotalOtherCompensationAmt>
      <IndivRcvdGreaterThan100KCnt>14</IndivRcvdGreaterThan100KCnt>
      <FormerOfcrEmployeesListedInd>false</FormerOfcrEmployeesListedInd>
      <TotalCompGreaterThan150KInd>true</TotalCompGreaterThan150KInd>
      <CompensationFromOtherSrcsInd>false</CompensationFromOtherSrcsInd>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>TouchPoint Business Solutions LLC</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>414 Calle Palo Colorado</AddressLine1Txt>
            <CityNm>Santa Barbara</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>93105</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>CFO Services</ServicesDesc>
        <CompensationAmt>193652</CompensationAmt>
      </ContractorCompensationGrp>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>One Story Architect Inc</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>121 El Paseo</AddressLine1Txt>
            <CityNm>Santa Barbara</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>93101</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>Architect Services</ServicesDesc>
        <CompensationAmt>148634</CompensationAmt>
      </ContractorCompensationGrp>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>Frank Schipper Construction Co</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>610 East Cota Street</AddressLine1Txt>
            <CityNm>Santa Barbara</CityNm>
            <StateAbbreviationCd>CA</StateAbbreviationCd>
            <ZIPCd>93103</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>Construction</ServicesDesc>
        <CompensationAmt>112321</CompensationAmt>
      </ContractorCompensationGrp>
      <CntrctRcvdGreaterThan100KCnt>3</CntrctRcvdGreaterThan100KCnt>
      <FundraisingAmt>334817</FundraisingAmt>
      <AllOtherContributionsAmt>1721932</AllOtherContributionsAmt>
      <NoncashContributionsAmt>18719</NoncashContributionsAmt>
      <TotalContributionsAmt>2056749</TotalContributionsAmt>
      <ProgramServiceRevenueGrp>
        <Desc>Patient Care Fees</Desc>
        <BusinessCd>541700</BusinessCd>
        <TotalRevenueColumnAmt>49965</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>49965</RelatedOrExemptFuncIncomeAmt>
      </ProgramServiceRevenueGrp>
      <ProgramServiceRevenueGrp>
        <Desc>Research Contracts</Desc>
        <BusinessCd>541700</BusinessCd>
        <TotalRevenueColumnAmt>2258524</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>2258524</RelatedOrExemptFuncIncomeAmt>
      </ProgramServiceRevenueGrp>
      <TotalProgramServiceRevenueAmt>2308489</TotalProgramServiceRevenueAmt>
      <InvestmentIncomeGrp>
        <TotalRevenueColumnAmt>510756</TotalRevenueColumnAmt>
        <ExclusionAmt>510756</ExclusionAmt>
      </InvestmentIncomeGrp>
      <IncmFromInvestBondProceedsGrp>
        <TotalRevenueColumnAmt>0</TotalRevenueColumnAmt>
      </IncmFromInvestBondProceedsGrp>
      <RoyaltiesRevenueGrp>
        <TotalRevenueColumnAmt>7150</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>7150</RelatedOrExemptFuncIncomeAmt>
      </RoyaltiesRevenueGrp>
      <GrossRentsGrp>
        <RealAmt>20808</RealAmt>
      </GrossRentsGrp>
      <RentalIncomeOrLossGrp>
        <RealAmt>20808</RealAmt>
      </RentalIncomeOrLossGrp>
      <NetRentalIncomeOrLossGrp>
        <TotalRevenueColumnAmt>20808</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>20808</RelatedOrExemptFuncIncomeAmt>
      </NetRentalIncomeOrLossGrp>
      <GrossAmountSalesAssetsGrp>
        <SecuritiesAmt>4044261</SecuritiesAmt>
        <OtherAmt>750000</OtherAmt>
      </GrossAmountSalesAssetsGrp>
      <LessCostOthBasisSalesExpnssGrp>
        <SecuritiesAmt>3892273</SecuritiesAmt>
        <OtherAmt>1305776</OtherAmt>
      </LessCostOthBasisSalesExpnssGrp>
      <GainOrLossGrp>
        <SecuritiesAmt>151988</SecuritiesAmt>
        <OtherAmt>-555776</OtherAmt>
      </GainOrLossGrp>
      <NetGainOrLossInvestmentsGrp>
        <TotalRevenueColumnAmt>-403788</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>-403788</RelatedOrExemptFuncIncomeAmt>
      </NetGainOrLossInvestmentsGrp>
      <FundraisingGrossIncomeAmt>46250</FundraisingGrossIncomeAmt>
      <ContriRptFundraisingEventAmt>334817</ContriRptFundraisingEventAmt>
      <FundraisingDirectExpensesAmt>157255</FundraisingDirectExpensesAmt>
      <NetIncmFromFundraisingEvtGrp>
        <TotalRevenueColumnAmt>-111005</TotalRevenueColumnAmt>
        <ExclusionAmt>-111005</ExclusionAmt>
      </NetIncmFromFundraisingEvtGrp>
      <NetIncomeFromGamingGrp>
        <TotalRevenueColumnAmt>0</TotalRevenueColumnAmt>
      </NetIncomeFromGamingGrp>
      <NetIncomeOrLossGrp>
        <TotalRevenueColumnAmt>0</TotalRevenueColumnAmt>
      </NetIncomeOrLossGrp>
      <OtherRevenueMiscGrp>
        <Desc>Other</Desc>
        <BusinessCd>541700</BusinessCd>
        <TotalRevenueColumnAmt>3962</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>3962</RelatedOrExemptFuncIncomeAmt>
      </OtherRevenueMiscGrp>
      <OtherRevenueTotalAmt>3962</OtherRevenueTotalAmt>
      <TotalRevenueGrp>
        <TotalRevenueColumnAmt>4393121</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>1936621</RelatedOrExemptFuncIncomeAmt>
        <ExclusionAmt>399751</ExclusionAmt>
      </TotalRevenueGrp>
      <GrantsToDomesticOrgsGrp>
        <TotalAmt>0</TotalAmt>
      </GrantsToDomesticOrgsGrp>
      <GrantsToDomesticIndividualsGrp>
        <TotalAmt>0</TotalAmt>
      </GrantsToDomesticIndividualsGrp>
      <ForeignGrantsGrp>
        <TotalAmt>0</TotalAmt>
      </ForeignGrantsGrp>
      <BenefitsToMembersGrp>
        <TotalAmt>0</TotalAmt>
      </BenefitsToMembersGrp>
      <CompCurrentOfcrDirectorsGrp>
        <TotalAmt>1023347</TotalAmt>
        <ProgramServicesAmt>648071</ProgramServicesAmt>
        <ManagementAndGeneralAmt>158542</ManagementAndGeneralAmt>
        <FundraisingAmt>216734</FundraisingAmt>
      </CompCurrentOfcrDirectorsGrp>
      <CompDisqualPersonsGrp>
        <TotalAmt>0</TotalAmt>
      </CompDisqualPersonsGrp>
      <OtherSalariesAndWagesGrp>
        <TotalAmt>3176474</TotalAmt>
        <ProgramServicesAmt>2538586</ProgramServicesAmt>
        <ManagementAndGeneralAmt>473108</ManagementAndGeneralAmt>
        <FundraisingAmt>164780</FundraisingAmt>
      </OtherSalariesAndWagesGrp>
      <PensionPlanContributionsGrp>
        <TotalAmt>54444</TotalAmt>
        <ProgramServicesAmt>34316</ProgramServicesAmt>
        <ManagementAndGeneralAmt>13448</ManagementAndGeneralAmt>
        <FundraisingAmt>6680</FundraisingAmt>
      </PensionPlanContributionsGrp>
      <OtherEmployeeBenefitsGrp>
        <TotalAmt>243699</TotalAmt>
        <ProgramServicesAmt>180294</ProgramServicesAmt>
        <ManagementAndGeneralAmt>44984</ManagementAndGeneralAmt>
        <FundraisingAmt>18421</FundraisingAmt>
      </OtherEmployeeBenefitsGrp>
      <PayrollTaxesGrp>
        <TotalAmt>307802</TotalAmt>
        <ProgramServicesAmt>235635</ProgramServicesAmt>
        <ManagementAndGeneralAmt>45397</ManagementAndGeneralAmt>
        <FundraisingAmt>26770</FundraisingAmt>
      </PayrollTaxesGrp>
      <FeesForServicesManagementGrp>
        <TotalAmt>0</TotalAmt>
      </FeesForServicesManagementGrp>
      <FeesForServicesLegalGrp>
        <TotalAmt>18154</TotalAmt>
        <ManagementAndGeneralAmt>18154</ManagementAndGeneralAmt>
      </FeesForServicesLegalGrp>
      <FeesForServicesAccountingGrp>
        <TotalAmt>26000</TotalAmt>
        <ManagementAndGeneralAmt>26000</ManagementAndGeneralAmt>
      </FeesForServicesAccountingGrp>
      <FeesForServicesLobbyingGrp>
        <TotalAmt>0</TotalAmt>
      </FeesForServicesLobbyingGrp>
      <FeesForServicesProfFundraising>
        <TotalAmt>0</TotalAmt>
      </FeesForServicesProfFundraising>
      <FeesForSrvcInvstMgmntFeesGrp>
        <TotalAmt>25110</TotalAmt>
        <ManagementAndGeneralAmt>25110</ManagementAndGeneralAmt>
      </FeesForSrvcInvstMgmntFeesGrp>
      <FeesForServicesOtherGrp>
        <TotalAmt>569366</TotalAmt>
        <ProgramServicesAmt>199565</ProgramServicesAmt>
        <ManagementAndGeneralAmt>302123</ManagementAndGeneralAmt>
        <FundraisingAmt>67678</FundraisingAmt>
      </FeesForServicesOtherGrp>
      <AdvertisingGrp>
        <TotalAmt>41278</TotalAmt>
        <ProgramServicesAmt>8108</ProgramServicesAmt>
        <ManagementAndGeneralAmt>2482</ManagementAndGeneralAmt>
        <FundraisingAmt>30688</FundraisingAmt>
      </AdvertisingGrp>
      <OfficeExpensesGrp>
        <TotalAmt>114689</TotalAmt>
        <ProgramServicesAmt>63820</ProgramServicesAmt>
        <ManagementAndGeneralAmt>33403</ManagementAndGeneralAmt>
        <FundraisingAmt>17466</FundraisingAmt>
      </OfficeExpensesGrp>
      <InformationTechnologyGrp>
        <TotalAmt>218162</TotalAmt>
        <ProgramServicesAmt>136160</ProgramServicesAmt>
        <ManagementAndGeneralAmt>37918</ManagementAndGeneralAmt>
        <FundraisingAmt>44084</FundraisingAmt>
      </InformationTechnologyGrp>
      <RoyaltiesGrp>
        <TotalAmt>2383</TotalAmt>
        <ProgramServicesAmt>2383</ProgramServicesAmt>
      </RoyaltiesGrp>
      <OccupancyGrp>
        <TotalAmt>172367</TotalAmt>
        <ProgramServicesAmt>112029</ProgramServicesAmt>
        <ManagementAndGeneralAmt>47241</ManagementAndGeneralAmt>
        <FundraisingAmt>13097</FundraisingAmt>
      </OccupancyGrp>
      <TravelGrp>
        <TotalAmt>41328</TotalAmt>
        <ProgramServicesAmt>35536</ProgramServicesAmt>
        <ManagementAndGeneralAmt>2956</ManagementAndGeneralAmt>
        <FundraisingAmt>2836</FundraisingAmt>
      </TravelGrp>
      <PymtTravelEntrtnmntPubOfclGrp>
        <TotalAmt>0</TotalAmt>
      </PymtTravelEntrtnmntPubOfclGrp>
      <ConferencesMeetingsGrp>
        <TotalAmt>95673</TotalAmt>
        <ProgramServicesAmt>80113</ProgramServicesAmt>
        <ManagementAndGeneralAmt>2460</ManagementAndGeneralAmt>
        <FundraisingAmt>13100</FundraisingAmt>
      </ConferencesMeetingsGrp>
      <InterestGrp>
        <TotalAmt>0</TotalAmt>
      </InterestGrp>
      <PaymentsToAffiliatesGrp>
        <TotalAmt>0</TotalAmt>
      </PaymentsToAffiliatesGrp>
      <DepreciationDepletionGrp>
        <TotalAmt>157400</TotalAmt>
        <ProgramServicesAmt>118392</ProgramServicesAmt>
        <ManagementAndGeneralAmt>21799</ManagementAndGeneralAmt>
        <FundraisingAmt>17209</FundraisingAmt>
      </DepreciationDepletionGrp>
      <InsuranceGrp>
        <TotalAmt>99329</TotalAmt>
        <ProgramServicesAmt>62467</ProgramServicesAmt>
        <ManagementAndGeneralAmt>29471</ManagementAndGeneralAmt>
        <FundraisingAmt>7391</FundraisingAmt>
      </InsuranceGrp>
      <OtherExpensesGrp>
        <Desc>Subject Reimbursement</Desc>
        <TotalAmt>296538</TotalAmt>
        <ProgramServicesAmt>296538</ProgramServicesAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>Campaign Expenses</Desc>
        <TotalAmt>203095</TotalAmt>
        <ProgramServicesAmt>195033</ProgramServicesAmt>
        <FundraisingAmt>8062</FundraisingAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>Lab Supplies</Desc>
        <TotalAmt>83677</TotalAmt>
        <ProgramServicesAmt>83677</ProgramServicesAmt>
      </OtherExpensesGrp>
      <AllOtherExpensesGrp>
        <TotalAmt>0</TotalAmt>
      </AllOtherExpensesGrp>
      <TotalFunctionalExpensesGrp>
        <TotalAmt>6970315</TotalAmt>
        <ProgramServicesAmt>5030723</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1284596</ManagementAndGeneralAmt>
        <FundraisingAmt>654996</FundraisingAmt>
      </TotalFunctionalExpensesGrp>
      <CashNonInterestBearingGrp>
        <BOYAmt>451787</BOYAmt>
        <EOYAmt>496358</EOYAmt>
      </CashNonInterestBearingGrp>
      <SavingsAndTempCashInvstGrp>
        <BOYAmt>5192133</BOYAmt>
        <EOYAmt>7773243</EOYAmt>
      </SavingsAndTempCashInvstGrp>
      <PledgesAndGrantsReceivableGrp>
        <BOYAmt>6268701</BOYAmt>
        <EOYAmt>1704404</EOYAmt>
      </PledgesAndGrantsReceivableGrp>
      <AccountsReceivableGrp>
        <BOYAmt>580057</BOYAmt>
        <EOYAmt>294184</EOYAmt>
      </AccountsReceivableGrp>
      <ReceivablesFromOfficersEtcGrp>
        <EOYAmt>0</EOYAmt>
      </ReceivablesFromOfficersEtcGrp>
      <RcvblFromDisqualifiedPrsnGrp>
        <EOYAmt>0</EOYAmt>
      </RcvblFromDisqualifiedPrsnGrp>
      <OthNotesLoansReceivableNetGrp>
        <EOYAmt>600000</EOYAmt>
      </OthNotesLoansReceivableNetGrp>
      <InventoriesForSaleOrUseGrp>
        <EOYAmt>0</EOYAmt>
      </InventoriesForSaleOrUseGrp>
      <PrepaidExpensesDefrdChargesGrp>
        <BOYAmt>48302</BOYAmt>
        <EOYAmt>71227</EOYAmt>
      </PrepaidExpensesDefrdChargesGrp>
      <LandBldgEquipCostOrOtherBssAmt>4000478</LandBldgEquipCostOrOtherBssAmt>
      <LandBldgEquipAccumDeprecAmt>1866148</LandBldgEquipAccumDeprecAmt>
      <LandBldgEquipBasisNetGrp>
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        <FormAndLineReferenceDesc>Part X : FIN48 Footnote</FormAndLineReferenceDesc>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 11b</FormAndLineReferenceDesc>
        <ExplanationTxt>A draft of the Form 990 is sent to each board member prior to the designated board meeting during which it will be discussed. The Form 990 is discussed at the designated board meeting and must be approved by a majority of the board before being filed.If the board is not scheduled to meet until after the filing deadline, a board representative will review a draft of the Form 990 and make a recommendation for filing. The draft form 990 will then be reviewed by the entire board at the next scheduled meeting.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>Each board member is asked to complete a conflict of interest form annually, which is reviewed by the objectivity and integrity in science committee (OISC). The OISC also reviews all research projects, publications, and scientific reports for conflicts of interest.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 15a</FormAndLineReferenceDesc>
        <ExplanationTxt>TThe Board of Trustees has established a Compensation Committee whose role is to provide the Board with Compensation recommendations for the Executive Director, Chief Scientific Officer, Chief Financial Officer, and any other highly compensated employees and consultants earning $200,000 or more per annum. The process for review and approval of compensation occurs upon initial hiring, whenever the term of employment is renewed or extended, and whenever the compensation is modified, unless a modification of compensation extends to substantially all employees. The President of the Board of Trustees is responsible for overseeing and evaluating executive performance on an annual basis. The supervisors of the highly compensated employees and consultants evaluate their performance. The Compensation Committee uses the following process to determine the compensation they will recommend to the board for approval for the executives and highly compensated employees and consultants: 1. Conduct research and obtain appropriate comparability or benchmarking data documenting compensation levels and benefits for similarly qualified individuals in comparable positions at similar organizations. Data may include salary and benefit compensation studies by independent sources, industry surveys, written job offers for positions at similar organizations, and information obtained from IRS Form 990 filings of similar organizations. 2. Carefully consider the performance reviews and supervisors recommendations regarding appropriate compensation.3. Determine the compensation to be recommended to the Board for approval, and contemporaneously document the basis for these recommendations, including the data on which it relied, the date it was discussed, the members present for the discussion, and the results of the vote.4. Present the Committees compensation recommendations to the full Board for approval, with approval documented in the minutes of the Board.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 15b</FormAndLineReferenceDesc>
        <ExplanationTxt>The Board of Trustees has established a Compensation Committee whose role is to provide the Board with Compensation recommendations for the Executive Director, Chief Scientific Officer, Chief Financial Officer, and any other highly compensated employees and consultants earning $200,000 or more per annum. The process for review and approval of compensation occurs upon initial hiring, whenever the term of employment is renewed or extended, and whenever the compensation is modified, unless a modification of compensation extends to substantially all employees. The President of the Board of Trustees is responsible for overseeing and evaluating executive performance on an annual basis. The supervisors of the highly compensated employees and consultants evaluate their performance. The Compensation Committee uses the following process to determine the compensation they will recommend to the board for approval for the executives and highly compensated employees and consultants: 1. Conduct research and obtain appropriate comparability or benchmarking data documenting compensation levels and benefits for similarly qualified individuals in comparable positions at similar organizations. Data may include salary and benefit compensation studies by independent sources, industry surveys, written job offers for positions at similar organizations, and information obtained from IRS Form 990 filings of similar organizations. 2. Carefully consider the performance reviews and supervisors recommendations regarding appropriate compensation.3. Determine the compensation to be recommended to the Board for approval, and contemporaneously document the basis for these recommendations, including the data on which it relied, the date it was discussed, the members present for the discussion, and the results of the vote.4. Present the Committees compensation recommendations to the full Board for approval, with approval documented in the minutes of the Board.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section C, Line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>Governing documents and conflict of interest policy are available to the general public upon written request. In addition, the most recent audited financial statements and donor privacy policy are posted on the organization's website.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>