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      <Form990PartVIISectionAGrp>
        <PersonNm>Vincent Lo Re</PersonNm>
        <TitleTxt>Immediate Past President</TitleTxt>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Caitlin Knox</PersonNm>
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        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Tobias Gerhard</PersonNm>
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        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
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        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>James Vrac</PersonNm>
        <TitleTxt>Executive Secretary</TitleTxt>
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        <AverageHoursPerWeekRltdOrgRt>0.00</AverageHoursPerWeekRltdOrgRt>
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          <PersonNm>Kellen Company</PersonNm>
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          <USAddress>
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            <CityNm>Atlanta</CityNm>
            <StateAbbreviationCd>GA</StateAbbreviationCd>
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      <ContractorCompensationGrp>
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          <PersonNm>Bella Opr AS</PersonNm>
        </ContractorName>
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          <ForeignAddress>
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      <ContractorCompensationGrp>
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          <PersonNm>Langelinie Pavillonen</PersonNm>
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      <ProgramServiceRevenueGrp>
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        <ExclusionAmt>56674</ExclusionAmt>
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        <UnrelatedBusinessRevenueAmt>0</UnrelatedBusinessRevenueAmt>
        <ExclusionAmt>56674</ExclusionAmt>
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      <InfoInScheduleOPartIXInd>X</InfoInScheduleOPartIXInd>
      <ForeignGrantsGrp>
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        <ProgramServicesAmt>148360</ProgramServicesAmt>
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        <ProgramServicesAmt>312310</ProgramServicesAmt>
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      <FeesForServicesAccountingGrp>
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      <FeesForServicesOtherGrp>
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        <ProgramServicesAmt>108794</ProgramServicesAmt>
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      <AdvertisingGrp>
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        <ProgramServicesAmt>8760</ProgramServicesAmt>
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        <ProgramServicesAmt>517114</ProgramServicesAmt>
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      <InformationTechnologyGrp>
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        <ProgramServicesAmt>74991</ProgramServicesAmt>
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        <Desc>Social Programs</Desc>
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        <ProgramServicesAmt>241491</ProgramServicesAmt>
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      <OtherExpensesGrp>
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      <OtherExpensesGrp>
        <Desc>Other</Desc>
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      <AllOtherExpensesGrp>
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        <ProgramServicesAmt>22003</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1266</ManagementAndGeneralAmt>
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      <TotalFunctionalExpensesGrp>
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        <ProgramServicesAmt>2667574</ProgramServicesAmt>
        <ManagementAndGeneralAmt>286185</ManagementAndGeneralAmt>
        <FundraisingAmt>0</FundraisingAmt>
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        <EOYAmt>959090</EOYAmt>
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      <AccountsReceivableGrp>
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        <EOYAmt>141166</EOYAmt>
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      <PrepaidExpensesDefrdChargesGrp>
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        <EOYAmt>610295</EOYAmt>
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      <InvestmentsPubTradedSecGrp>
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        <EOYAmt>2232450</EOYAmt>
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        <EOYAmt>3943001</EOYAmt>
      </TotalAssetsGrp>
      <AccountsPayableAccrExpnssGrp>
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        <EOYAmt>54047</EOYAmt>
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      <DeferredRevenueGrp>
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        <EOYAmt>926540</EOYAmt>
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      <TotalLiabilitiesGrp>
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        <EOYAmt>980587</EOYAmt>
      </TotalLiabilitiesGrp>
      <OrganizationFollowsFASB117Ind>X</OrganizationFollowsFASB117Ind>
      <NoDonorRestrictionNetAssetsGrp>
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        <EOYAmt>2962414</EOYAmt>
      </NoDonorRestrictionNetAssetsGrp>
      <TotalNetAssetsFundBalanceGrp>
        <BOYAmt>3501190</BOYAmt>
        <EOYAmt>2962414</EOYAmt>
      </TotalNetAssetsFundBalanceGrp>
      <TotLiabNetAssetsFundBalanceGrp>
        <BOYAmt>4224312</BOYAmt>
        <EOYAmt>3943001</EOYAmt>
      </TotLiabNetAssetsFundBalanceGrp>
      <ReconcilationRevenueExpnssAmt>-568366</ReconcilationRevenueExpnssAmt>
      <NetUnrlzdGainsLossesInvstAmt>29590</NetUnrlzdGainsLossesInvstAmt>
      <OtherChangesInNetAssetsAmt>0</OtherChangesInNetAssetsAmt>
      <MethodOfAccountingAccrualInd>X</MethodOfAccountingAccrualInd>
      <AccountantCompileOrReviewInd>false</AccountantCompileOrReviewInd>
      <FSAuditedInd>true</FSAuditedInd>
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        <CurrentTaxYearAmt>2328719</CurrentTaxYearAmt>
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        <CurrentTaxYearMinus1YearAmt>32417</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>56674</CurrentTaxYearAmt>
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      <InvestmentIncomeAndUBTIGrp>
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        <CurrentTaxYearMinus3YearsAmt>47760</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>28586</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>32417</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>56674</CurrentTaxYearAmt>
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      <PublicSupportPY509Pct>0.96330</PublicSupportPY509Pct>
      <InvestmentIncomeCYPct>0.03000</InvestmentIncomeCYPct>
      <InvestmentIncomePYPct>0.04000</InvestmentIncomePYPct>
      <ThirtyThrPctSuprtTestsCY509Ind>X</ThirtyThrPctSuprtTestsCY509Ind>
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    <IRS990ScheduleD documentId="990D">
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        <DepreciationAmt>15390</DepreciationAmt>
      </EquipmentGrp>
      <OtherLandBuildingsGrp>
        <OtherCostOrOtherBasisAmt>92450</OtherCostOrOtherBasisAmt>
        <DepreciationAmt>92450</DepreciationAmt>
      </OtherLandBuildingsGrp>
      <FootnoteTextInd>X</FootnoteTextInd>
      <TotalRevEtcAuditedFinclStmtAmt>2414983</TotalRevEtcAuditedFinclStmtAmt>
      <NetUnrealizedGainsInvstAmt>29590</NetUnrealizedGainsInvstAmt>
      <RevenueNotReportedAmt>29590</RevenueNotReportedAmt>
      <RevenueSubtotalAmt>2385393</RevenueSubtotalAmt>
      <TotalRevenuePerForm990Amt>2385393</TotalRevenuePerForm990Amt>
      <TotExpnsEtcAuditedFinclStmtAmt>2953759</TotExpnsEtcAuditedFinclStmtAmt>
      <ExpensesSubtotalAmt>2953759</ExpensesSubtotalAmt>
      <TotalExpensesPerForm990Amt>2953759</TotalExpensesPerForm990Amt>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Footnote for uncertain tax position under FIN 48 (Part X)</FormAndLineReferenceDesc>
        <ExplanationTxt>ISPE is exempt from the payment of income taxes on its exempt activities under Section 501 (c)(3) of the Internal Revenue Code.ISPE follows the Financial Accounting Standards Board Accounting Standards Codification, which provides guidance on accounting for uncertainty in income taxes recognized in ISPEs financial statements, if any. At year end, ISPE had no unrecognized tax benefits related to uncertain tax positions in its information return that would qualify for either recognition or disclosure in its financial statements. ISPEs policy would be to recognize interest and penalties on tax positions related to its unrecognized tax benefits in income tax expense in the financial statements. Through year end, there have been no matters that would have resulted in an accrual for interest and/or penalties.Generally, the tax years before 2019 are no longer subject to examination by federal, state, or local taxing authorities.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleD>
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      <GrantRecordsMaintainedInd>true</GrantRecordsMaintainedInd>
      <AccountActivitiesOutsideUSGrp>
        <RegionTxt>East Asia and the Pacific</RegionTxt>
        <TypeOfActivitiesConductedTxt>Program services</TypeOfActivitiesConductedTxt>
        <SpecificServicesProvidedTxt>Program</SpecificServicesProvidedTxt>
        <RegionTotalExpendituresAmt>31786</RegionTotalExpendituresAmt>
      </AccountActivitiesOutsideUSGrp>
      <AccountActivitiesOutsideUSGrp>
        <RegionTxt>Europe including Iceland and Greenland</RegionTxt>
        <TypeOfActivitiesConductedTxt>Program services</TypeOfActivitiesConductedTxt>
        <SpecificServicesProvidedTxt>Program</SpecificServicesProvidedTxt>
        <RegionTotalExpendituresAmt>1906610</RegionTotalExpendituresAmt>
      </AccountActivitiesOutsideUSGrp>
      <AccountActivitiesOutsideUSGrp>
        <RegionTxt>Sub-Saharan Africa</RegionTxt>
        <TypeOfActivitiesConductedTxt>Program services</TypeOfActivitiesConductedTxt>
        <SpecificServicesProvidedTxt>Program</SpecificServicesProvidedTxt>
        <RegionTotalExpendituresAmt>31786</RegionTotalExpendituresAmt>
      </AccountActivitiesOutsideUSGrp>
      <SubtotalSpentAmt>1970182</SubtotalSpentAmt>
      <TotalSpentAmt>1970182</TotalSpentAmt>
      <ForeignIndividualsGrantsGrp>
        <TypeOfAssistanceTxt>Asian Meeting Grants</TypeOfAssistanceTxt>
        <RecipientCnt>140</RecipientCnt>
        <CashGrantAmt>19319</CashGrantAmt>
      </ForeignIndividualsGrantsGrp>
      <ForeignIndividualsGrantsGrp>
        <TypeOfAssistanceTxt>Annual Meeting Grants</TypeOfAssistanceTxt>
        <RecipientCnt>94</RecipientCnt>
        <CashGrantAmt>112636</CashGrantAmt>
      </ForeignIndividualsGrantsGrp>
      <ForeignIndividualsGrantsGrp>
        <TypeOfAssistanceTxt>Mid-Year Meeting Grants</TypeOfAssistanceTxt>
        <RecipientCnt>43</RecipientCnt>
        <CashGrantAmt>16405</CashGrantAmt>
      </ForeignIndividualsGrantsGrp>
      <TransferToForeignCorpInd>false</TransferToForeignCorpInd>
      <InterestInForeignTrustInd>false</InterestInForeignTrustInd>
      <ForeignCorpOwnershipInd>false</ForeignCorpOwnershipInd>
      <PassiveForeignInvestmestCoInd>false</PassiveForeignInvestmestCoInd>
      <ForeignPartnershipInd>false</ForeignPartnershipInd>
      <BoycottCountriesInd>false</BoycottCountriesInd>
    </IRS990ScheduleF>
    <IRS990ScheduleO documentId="990O">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Management duties delegation Part VI line 3</FormAndLineReferenceDesc>
        <ExplanationTxt>Effective January 2000, ISPE entered into an agreement with PAI Management Corporation, an association management company, to receive management and administrative services. This agreement may be terminated by either ISPE or the management company, upon proper notification, given a 90-day notification. As stated in the contract, any amendments to fees are approved through the annual ISPE budget.Kellen Company assumed the provision of management service to ISPE effective July 1, 2022.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Members or stockholder classes and rights Part VI line 6</FormAndLineReferenceDesc>
        <ExplanationTxt>Members are individuals or organizations dedicated to pharmacoepidemiology research, education, and practice and its related description lines, and demonstrates and interest in promoting the growth of this field. All members have voting rights.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Member election for additional members Part VI line 7a</FormAndLineReferenceDesc>
        <ExplanationTxt>Every member has the right to elect members of the Organizations governing body.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Governing body decisions Part VI line 7b</FormAndLineReferenceDesc>
        <ExplanationTxt>The by-laws may be amended or repealed by action of the Board of Directors or by action of the general members.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990 governing body review Part VI line 11</FormAndLineReferenceDesc>
        <ExplanationTxt>Form 990 is prepared by an outside independent certified public accounting firm and submitted to senior ISPE management prior to distribution to ISPEs Board of Directors. A draft of Form 990 is sent to the Board of Directors with a final version available to the board after it is filed with the IRS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Conflict of interest policy compliance Part VI line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>Conflict of interest discussed and resolved on a case by case basis as situations which could cause conflicts arise.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>CEO executive director top management comp Part VI line 15a</FormAndLineReferenceDesc>
        <ExplanationTxt>Compensation of ISPEs Executive Secretary is paid by PAI Management Corporation through a management services contract (in lieu of full time professional staff) under which PAI provides a scope of management, technology and accounting services which is agreed upon and approved on a yearly basis by the Board of Directors.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Other officer or key employee compensation Part VI line 15b</FormAndLineReferenceDesc>
        <ExplanationTxt>ISPE operates under a management services contract with an outsourced management company in lieu of full time professional staff.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Governing documents etc available to public Part VI line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>The Organization makes it governing documents, conflict of interest policy, and financial statements available to the public upon request.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>List of other fees for services expenses Part IX line 11g</FormAndLineReferenceDesc>
        <ExplanationTxt>Abstract Processing $28,027Other Professional Fees $80,767</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>General explanation attachment</FormAndLineReferenceDesc>
        <ExplanationTxt>Mission Statement:The International Society for Pharmacoepidemiology (ISPE) is a non-profit international professional membership organization dedicated to advancing the health of the public by providing a forum for the open exchange of scientific information and for the development of policy, education, and advocacy for the field of pharmacoepidemiology, including pharmacovigilance, drug utilization research, outcomes research, comparative effectiveness research, and therapeutic risk management.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>
