2024-10-28T11:02:57+00:00 2023-12-31 350921680 CROWE LLP 5810 TENNYSON PARKWAY Suite 450 Plano TX 750244112 990PF 2023-01-01 411563321 THE MCKNIGHT ENDOWMENT FUND FOR NEUROSCIENCE MCKN 6123334220 710 S 2ND ST STE 400 Minneapolis MN 554012290 Nichol Higdon VP of Finance and Operations 2024-10-28 true Lori McLaughlin P01231707 2147775200 2024-10-28 2023 2024-10-15 13:58:12Z X 25588 X 3800550 0 0 0 0 0 0 0 0 3800550 0 0 34000 34000 0 0 0 0 9885 0 0 9885 132000 0 0 132000 0 0 0 0 0 0 0 396421 396421 19674 0 0 19674 591980 0 0 591980 3207413 3207413 3799393 0 0 3799393 1157 0 0 24431 25588 25588 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 24431 25588 25588 0 0 0 0 0 0 X 24431 25588 24431 25588 24431 25588 24431 1157 0 25588 0 25588 0 0 0 0 0 0 0 0 0 false false false false false false false true true MN true true false false false true https://www.mcknight.org/programs/the-mcknight-endowment-fund-for-neuroscience/ Nichol Higdon 6123334220 710 S 2ND ST STE 400 Minneapolis MN 554012290 false false false false true false false false false false false false false false false false false false false false false false Kara Carlisle 710 Second Street South Suite 400 Minneapolis MN 554012290 DIRECTOR (Through June 2023) 0.200 0 0 0 Kelsey Martin MD PhD 710 S 2ND ST STE 400 Minneapolis MN 554012290 Vice President 1.100 9000 0 0 Stephanie Duffy 710 S 2ND ST STE 400 Minneapolis MN 554012290 Secretary/Treasurer (Beginning June 2023) 0.200 0 0 0 Catherine Dulac 710 S 2ND ST STE 400 Minneapolis MN 554012290 Director 0.200 1000 0 0 Dana Anderson 710 S 2ND ST STE 400 Minneapolis MN 554012290 Director 0.200 0 0 0 J Anthony Movshon PhD 710 S 2ND ST STE 400 Minneapolis MN 554012290 President 1.300 11000 0 0 Leslie Vosshall 710 S 2ND ST STE 400 Minneapolis MN 554012290 Director 0.200 1000 0 0 Markus Meister 710 S 2ND ST STE 400 Minneapolis MN 554012290 Director 0.400 2000 0 0 Michael D Ehlers MD PhD 710 S 2ND ST STE 400 Minneapolis MN 554012290 Director 0.200 0 0 0 Ming Guo MD PhD 710 S 2ND ST STE 400 Minneapolis MN 554012290 Director 1.100 5000 0 0 Richard Mooney 710 S 2ND ST STE 400 Minneapolis MN 554012290 Director 1.100 5000 0 0 ERIKA BINGER 710 Second Street South Suite 400 Minneapolis MN 554012290 SECRETARY/TREASURER (Through June 2023) 0.900 0 0 0 0 The McKnight Foundation 710 S 2ND ST STE 400 Minneapolis MN 554012290 Administrative Services 100000 See Supplemental Information 380575 N/A 0 0 1130334 0 1130334 0 1130334 16955 1113379 55669 X 3799393 0 0 3799393 X 0 0 0 39 39 0 0 0 33 33 3799393 3772957 3593792 3456889 14623031 3125000 3120612 3125000 3150000 12520612 674393 652345 468792 306889 2102419 37113 37157 30677 27950 132896 NONE NONE MEFN Selection Committee 710 S 2ND ST STE 400 Minneapolis MN 554012290 6123334220 neuro@mcknight.org SEE SUPPLEMENTAL INFORMATION SEE SUPPLEMENTAL INFORMATION See Supplemental Information Albert Einstein College of Medicine 1300 Morris Park Ave Ste 402 New York NY 10461 NONE PC Unravelling the mechanisms of synapse development, from molecules to behavior. Principal Investigator: Dr. Peri Kurshan 75000 Brigham and Women's HospitalHarvard Medical School 60 Fenwood Rd Hale Building Room 70 02L Boston MA 02115 NONE PC The Neurobiology of Glioma: Understanding Malignant Neural Circuits Instructing Tumor Growth. Principal Investigator: Humsa Venkatesh,Ph.D. 100000 Cold Spring Harbor Laboratory 1 Bungtown Road Beckman Room 319 Cold Spring Harbor NY 11724 NONE PC Uncovering the Molecular Basis of Microglial Function in the Stimulated Brain. Principal Investigator: Lucas Cheadle 75000 Columbia University 3227 Broadway New York NY 10027 NONE PC Connectrome-constrained Models of Adaptive Behavior. Principal Investigator: Ashok Litwin-Kumar 75000 Columbia University 3227 Broadway New York NY 10027 NONE PC Cortical circuits for perceiving visual form. Principal Investigator: Dr. Yasmine El-Shamayleh 75000 Columbia University 3227 Broadway New York NY 10027 NONE PC Neural Mechanisms of Courtship and Monogamy. Principal Investigator: Dr. Vikram Gadagkar 75000 Columbia University 3227 Broadway New York NY 10027 NONE PC Skin-brain axis for rewarding touch behaviors. Principal Investigator: Dr. Ishmail Abdus-Saboor 75000 Fred Hutchinson Cancer Research Center 1100 Fairview Ave N PO Box 19024 Seattle WA 98109 NONE PC Adipocyte-brain mitochondrial signaling and its impacts on brain function. Principal Investigator: Akhila Rajan,Ph.D. 100000 Harvard Medical School 220 Longwood Avenue Armenise 429 Boston MA 02115 NONE PC Multiscale Neural Network Models to Infer Functional Motifs in the Brain. Principal Investigator: Kanaka Rajan, Ph.D. 75000 Massachusetts General Hospital 185 Cambridge Street Simches Resear ch Center Room 6808 Boston MA 02114 NONE PC Development, Function, and Dysfunction of Somatosensory and Viscerosensory Systems in Autism Spectrum Disorder. Principal Investigator: Lauren Orefice, Ph.D. 75000 Massachusetts Institute of Technology 60 Vassar St Room 39-229 Cambridge MA 02139 NONE PC Linking Neural Circuits and Fluid Dynamics in the Sleeping Brain. Principal Investigator: Laura Lewis 75000 Max Planck Florida Institute 1 Max Planck Way Jupiter FL 33458 NONE PC Synaptic mechanisms and network dynamics underlying motor learning. Principal Investigator: Dr. Hidehiko Inagaki 75000 New York University 4 Washington Place Room 621 New York NY 10003 NONE PC Coordinate Transforms in the Mouse Cortex. Principal Investigator: David Schneider 75000 New York University 4 Washington Place Room 621 New York NY 10003 NONE PC Modulation of striatal cells and synapses by dopamine movement signals. Principal Investigator: Dr. Tanya Sippy 75000 New York University 4 Washington Place Room 621 New York NY 10003 NONE PC Neural Circuit Mechanisms of Inference. Principal Investigator: Christine Constantinople, Ph.D 75000 Northwestern University Feinberg School of Medicine 303 E Superior St Lurie 7-109 Chicago IL 60611 NONE GOV Dissecting the Gut-brain Dynamics Underlying Anorexia. Principal Investigator: Lisa Beutler 100000 Oregon Health & Science University 3181 SW Sam Jackson Park Road L623 Portland OR 97239 NONE GOV Mechanosensation for guiding cellular morphology. Principal Investigator: Dr. Swetha Murthy 75000 St Jude Children's Research Hospital 262 Danny Thomas Place Memphis TN 38112 NONE PC Identifying Brain Circuits that Connect Respiration and Cognitive State. Principal Investigator: Lindsey Schwarz 100000 Stanford University 371 Jane Stanford Way Stanford CA 94305 NONE PC How Does the Brain Compute Using Activity Distributed Across Populations and Brain Areas? Principal Investigator: Shaul Druckmann 75000 Stanford University 371 Jane Stanford Way Stanford CA 94305 NONE PC Machine Learning Methods for Discovering Structure in Neural and Behavioral Data. Principal Investigator: Dr. Scott Linderman 75000 Stanford University School of Medicine 401 Quarry Rd Palo Alto CA 94304 NONE PC Neuron-to-OPC synapses in adaptive and maladaptive myelination. Principal Investigator: Juliet K. Knowles, MD, PhD 100000 Syracuse University 640 Skytop Road Syracuse NY 13244 NONE PC Two-photon tracking technology to read and manipulate neural patterns in freely moving animals. Principal Investigator: Mirna Mihovilovic Skanata 100000 The Regents of the University of California 201 Gilman Hall UC Berkeley Berkeley CA 94702 NONE GOV Evolution of neural diversity and patterning in the visual system. Principal Investigator: Dr. Karthik Shekhar 75000 The Regents of the University of California 201 Gilman Hall UC Berkeley Berkeley CA 94702 NONE GOV Illuminating Oxytocin Signaling in the Brain with Near-Infrared Fluorescent Nanosensors. Principal Investigator: Markita Landry, Ph.D. 75000 The Regents of the University of California 142 Weill Hall 3200 Berkeley CA 94702 NONE GOV Neurotensin mediated regulation of hedonic feeding behavior and obesity. Principal Investigator: Stephan Lammel Ph.D. 100000 The Trustees of Princeton University Washington Road Princeton NJ 08544 NONE PC Proportional-Integral Feedback in a Biological 'Gyroscope'. Principal Investigator: Bradley Dickerson, Ph.D. 75000 University of Alabama at Birmingham 1825 University Blvd SHEL 910 Birmingham AL 35294 NONE PC Leveraging Single-cell Epigenomics for Targeted Manipulation of Drug-activated Ensemble. Principal Investigator: Jeremy Day & Ian Maze 100000 University of Illinois at Chicago 840 W Taylor St Chicago IL 60607 NONE GOV Sub-10 nm spatial profiling of synaptic proteins and RNA transcripts with high-isotropy expansion microscopy using a highly homogenous hydrogel constructed from tetrahedron-like monomers. Principal Investigator: Ruixuan Gao, Ph.D. 100000 University of Iowa 169 Newton Rd 2400 PBDB Iowa City IA 52242 NONE GOV Brain-wide Electrical Connectivity in Migraine: Toward the Development of Network Based Therapeutics. Principal Investigator: Rainbo Hultman 100000 University of Michigan 1105 North University Room 4218 Ann Arbor MI 48109 NONE PC A Feminist Framing of Fruitless: Maleness as a Suppression of Female Neural Programs. Principal Investigator: E. Josie Clowney 74913 University of Michigan 109 Zina Pitcher Place Ann Arbor MI 48109 NONE PC Cellular Mechanisms Controlling Circadian Rythms. Principal Investigator: Swathi Yadlapalli 75000 University of North Carolina - Chapel Hill 116 Manning Drive Chapel Hill NC 27599 NONE PC Elucidating the Neural Basis of Pain Unpleasantness: Circuits and New Therapeutics to End the Dual Epidemic of Chronic Pain and Opioid Addiction. Principal Investigator: Gregory Scherrer 100000 University of Utah 50 N Medical Drive Salt Lake City UT 84132 NONE PC Neuropeptidergic Cortical Control of Social Isolation. Principal Investigator: Dr. Moriel Zelikowsky 75000 University of Washington 850 Republican Street S441 Seattle WA 98109 NONE GOV Massively parallel, high throughput engineering of optogenetic biosensors for neuronal signaling. Principal Investigator: Andre Berndt, Ph.D. 100000 UT Southwestern Medical Center 6001 Forest Park Rd Dallas TX 75214 NONE GOV Understanding the Construction and Function of Glycinergic Post-Synaptic Assemblies. Principal Investigator: Weiwei Wang, Ph.D. 75000 Yale University 333 Cedar St Department of Neurosci ence PO Box 2 New Haven CT 06520 NONE PC Mechanism and functions of repeat expansion self-exonization in C9orf72 ALS/FTD. Principal Investigator: Junjie Guo, Ph.D. 100000 Yale University School of Medicine 333 Cedar St Department of Neurosci ence PO Box 2 New Haven CT 06520 NONE PC From Gut to Brain: Understanding the Propagation of Parkinson's Disease. Principal Investigator: Rui Chang & Sreeganga Chandra 100000 California Institute of Technology 1200 EAST CALIFORNIA BLVD PASADENA CA 91125 NONE PC McKnight Pecot Fellowship 2023. Principal Investigator: Zinn, Dr. Kai, Ph.D. 16500 Columbia University 3227 Broadway New York NY 10027 NONE PC McKnight Pecot Fellowship 2023. Principal Investigator: Behnia, Rudy, Ph.D. 16500 Johns Hopkins University 3400 NORTH CHARLES STREET Baltimore MD 21218 NONE PC McKnight Pecot Fellowship 2023. Principal Investigator: Watanabe, Dr. Shigeki, Ph.D. 16500 Texas State University Department of Psychology 601 UNIVERSITY DRIVE San Marcos TX 78666 NONE GOV McKnight Pecot Fellowship 2023. Principal Investigator: Westerberg, Carmen, Ph.D. 16500 The Regents of the University of California 201 Gilman Hall UC Berkeley Berkeley CA 94702 NONE GOV McKnight Pecot Fellowship 2023. Principal Investigator: Isacoff, Dr. Ehud Y., Ph.D. 16500 3207413 Albert Einstein College of Medicine 1300 Morris Park Ave Ste 402 New York NY 10461 NONE PC Unravelling the mechanisms of synapse development, from molecules to behavior. Principal Investigator: Dr. Peri Kurshan 150000 Brigham and Women's HospitalHarvard Medical School 60 Fenwood Rd Hale Building Room 70 02L Boston MA 02115 NONE PC The Neurobiology of Glioma: Understanding Malignant Neural Circuits Instructing Tumor Growth. Principal Investigator: Humsa Venkatesh,Ph.D. 300000 Columbia University 3227 Broadway New York NY 10027 NONE PC Skin-brain axis for rewarding touch behaviors. Principal Investigator: Dr. Ishmail Abdus-Saboor 150000 Columbia University 3227 Broadway New York NY 10027 NONE PC Neural Mechanisms of Courtship and Monogamy. Principal Investigator: Dr. Vikram Gadagkar 150000 Columbia University 3227 Broadway New York NY 10027 NONE PC Cortical circuits for perceiving visual form. Principal Investigator: Dr. Yasmine El-Shamayleh 150000 Fred Hutchinson Cancer Research Center 1100 Fairview Ave N PO Box 19024 Seattle WA 98109 NONE PC Adipocyte-brain mitochondrial signaling and its impacts on brain function. Principal Investigator: Akhila Rajan,Ph.D. 300000 Max Planck Florida Institute 1 Max Planck Way Jupiter FL 33458 NONE PC Synaptic mechanisms and network dynamics underlying motor learning. Principal Investigator: Dr. Hidehiko Inagaki 150000 New York University 4 Washington Place Room 621 New York NY 10003 NONE PC Modulation of striatal cells and synapses by dopamine movement signals. Principal Investigator: Dr. Tanya Sippy 150000 Oregon Health & Science University 3181 SW Sam Jackson Park Road L623 Portland OR 97239 NONE GOV Mechanosensation for guiding cellular morphology. Principal Investigator: Dr. Swetha Murthy 150000 Stanford University 371 Jane Stanford Way Stanford CA 94305 NONE PC Machine Learning Methods for Discovering Structure in Neural and Behavioral Data. Principal Investigator: Dr. Scott Linderman 150000 Stanford University School of Medicine 401 Quarry Rd Palo Alto CA 94304 NONE PC Neuron-to-OPC synapses in adaptive and maladaptive myelination. Principal Investigator: Juliet K. Knowles, MD, PhD 300000 The Regents of the University of California 201 Gilman Hall UC Berkeley Berkeley CA 94702 NONE GOV Evolution of neural diversity and patterning in the visual system. Principal Investigator: Dr. Karthik Shekhar 150000 University of Utah 50 N Medical Drive Salt Lake City UT 84132 NONE PC Neuropeptidergic Cortical Control of Social Isolation. Principal Investigator: Dr. Moriel Zelikowsky 150000 Yale University 333 Cedar St Department of Neurosci ence PO Box 2 New Haven CT 06520 NONE PC Mechanism and functions of repeat expansion self-exonization in C9orf72 ALS/FTD. Principal Investigator: Junjie Guo, Ph.D. 300000 2700000 0 0 0 0 false false false false false false false false false false X X 1 THE MCKNIGHT FOUNDATION 710 S 2ND ST STE 400 MINNEAPOLIS MN 554012290 3800550 X PROFESSIONAL FEES 9885 9885 ANNUAL CONFERENCE FORM 990-PF, PART VIII-A In June 2023, the McKnight Conference on Neuroscience was held its annual conference on neuroscience that was attended by 91 neuroscientists, members of the MEFN Board of Directors, the Awards Selection Committee, and 3 Doupe Fellows, and other invited guests. 14 McKnight award recipients and 6 guest speakers presented the findings of their brain research projects over the course of the June weekend. Special lecture topics included: "SYNAPSES LOST AND FOUND IN DEVELOPMENT AND ALZHEIMER'S DISEASE," PRESENTED BY CARLA SHATZ; "DISCOVERING AND REGULATING BRAIN NETWORKS UNDERLYING EMOTION," PRESENTED BY KAFUI DZIRASA; AND "UPDATE ON THE NIH BRAIN INITIATIVE," PRESENTED BY NIH BRAIN INITIATIVE DIRECTOR JOHN NGAI. Brain Disease Workshop: "AUTISM SPECTRUM DISORDERS INCLUDED RESEARCHERS DRS. SHAFALI SPURLING JESTE (UNIVERSITY OF SOUTHERN CALIFORNIA), AMI KLIN (EMORY UNIVERSITY), AND LOREN FRANK (UNIVERSITY OF CALIFORNIA SAN FRANCISCO). Other sessions included three (3) session of award recipient scientific speaking presentations, a technology workshop, and a technology demonstration. Each presentation included a 15 minutes question and answer session so that the conference audience benefited from an open discussion of the research works presented. In addition, the technology demonstration was interactive and included open discussions. The McKnight Conference on Neuroscience provides a forum for: 1) sharing of research developments by and between McKnight awardees through the formal presentations; 2) sharing of research work in informal discussions; and 3) monitoring by the board of directors and review committee members of the research work being supported by the McKnight Endowment Fund for Neuroscience. The next McKnight Conference on Neuroscience is scheduled to be held June 7-10, 2024, in Aspen, CO. Fourteen recent recipients of a McKnight award and five guest speakers will present the findings of their brain research projects. AWARDS FORM 990-PF, PART XIV, LINE 2B The McKnight Endowment Fund for Neuroscience is an independent charitable organization established by The McKnight Foundation to carry out the intention of its founder, William L. McKnight (1887-1979). Mr. McKnight, who led the 3M company for three decades, had a personal interest in memory and its diseases and set aside part of his legacy to bring hope to those suffering from brain injury or disease and cognitive impairment. The Endowment Fund fulfills this mission by supporting innovative research in neuroscience through three competitive annual awards. The awards complement each other to support both young and established neuroscientists and to encourage interdisciplinary collaboration. Each in a different way, the three programs seek out investigators whose research shows promise in bringing society closer to preventions, treatments, and cures for many devastating diseases. Research supported by the Endowment Fund has furthered understanding of Alzheimer's disease, Parkinson's disease, spinal cord injuries, and many other cognitive impairments. In 2021, the Endowment Fund created a Fellowship for McKnight awardees to hire an undergraduate student from a community underrepresented in neuroscience. The Endowment Fund is led by a board of eminent neuroscientists, with administrative support from the McKnight Foundation. Each award has its own selection committee, also made up of prominent scientists. The committee recommends awardees, and the board has the final approval. McKnight Scholar Awards The McKnight Scholar Awards encourage neuroscientists in the early stages of their careers to focus on critical problems in brain science. These awards support young scientists who hold a M.D. and/or Ph.D. degree, who have completed formal postdoctoral training, and who demonstrate a commitment to neuroscience. The Endowment Fund especially seeks applicants who demonstrate an interest in solving important problems in relevant areas of neuroscience, including the translation of basic research to clinical neuroscience. For descriptions of previous awards, please go to the Endowment Fund website. Each year, up to ten Scholars are selected to receive three years of support at $75,000 per year. Funds may be used for direct costs in any way that will facilitate development of the Scholar's research program. Scholars must have authorization from the home institution to work in the U.S. and must hold full time appointments at the rank of assistant professor at their sponsoring institution; scientists holding other titles such as research assistant professor, adjunct assistant professor, assistant professor research track, visiting professor, or instructor are not eligible. If the host institution does not use professorial titles, a letter from a senior institutional official (e.g., Dean or Director of Research) must confirm that the applicant has his/her own dedicated institutional resources, laboratory space, and/or facilities. Application materials are due in early January and can be uploaded by accessing the online URL set up for this purpose. Each applicant must ensure that four letters of reference are submitted to an email account; these letters are an integral part of the application. Awards are announced in June and begin on July 1. McKnight Neurobiology of Brain Disorders Award The Neurobiology of Brain Disorder Awards, support neuroscientists who are working to apply the knowledge achieved through basic or clinical research to human brain disorders and who address the biology and mechanisms of neurological and psychiatric disorders. They are designed to stimulate innovative approaches that might lead to therapies and cures. Competitive projects would include those that provide mechanistic insights into neurological functions at the synaptic, cellular, molecular, genetic, or behavioral level across different species, including humans and vertebrate and invertebrate model organisms, and that incorporate fundamentally new approaches that provide potential paths for therapeutic interventions. Collaborative and cross-disciplinary applications are encouraged. For descriptions of previous awards, please go to the Endowment Fund website. The first step is to submit a two-page letter of intent describing the project and how the research will be applied to improving the understanding of a brain disorder or disease. Investigators must have authorization from the home institution to work in the U.S. and must hold full time appointments at the rank of assistant professor or higher at the sponsoring institution; scientists holding other titles such as research professor, adjunct professor, professor research track, visiting professor, or instructor are not eligible. If the host institution does not use professorial titles, a letter from a senior institutional official (e.g., Dean or Director of Research) must confirm that the applicant has his/her own dedicated institutional resources, laboratory space, and/or facilities. Funds may be used toward a variety of research activities, except the recipient's salary. The selection committee will invite a few applicants to submit detailed proposals, from which up to four awards will be selected. Each provides $100,000 annually for three years. Letters of intent are due in November and can be uploaded by accessing the online URL set up for this purpose. Awards are announced in June and begin in August of the following year. McKnight Matthew Pecot Fellowship The McKnight Pecot Fellowship, created in 2021, is named in honor of McKnight Scholar Awardee Matthew Pecot, who died in 2019. Matthew was a brilliant BIPOC neuroscientist at Harvard Medical School and a 2017 McKnight Scholar Awardee. He received his McKnight award for his work on identifying molecular principles underlying synaptic specificity. Matthew's McKnight work has contributed to identifying defects in neural connectivity, which underlie many neural psychiatric diseases. Up to six current McKnight Endowment Fund awardees are selected to receive $16,500 to hire an underrepresented college student to perform research in the McKnight awardee's lab. In addition to supervising the Fellow's research activities, the McKnight awardee will provide mentorship and networking opportunities for the Fellow. Additionally, the Fellow will be invited to the McKnight Endowment Fund annual conference. The Pecot Fellowship is open to all former and current McKnight neuroscientists. The nomination application includes a recommendation from the McKnight awardee; an essay on a scientific topic by the undergraduate who is being nominated; and the undergraduate's resume. Nominations are submitted in February/March and awardees are notified in April/May. A subcommittee of McKnight Endowment for Neuroscience board members selects the awards. MISCELLANEOUS EXPENSE 21 21 COMMUNICATION EXPENSE 6386 6386 COMPUTER SERVICES 13267 13267 ADMINISTRATIVE SERVICE FEES 100000 100000 COMMITTEE FEES 32000 32000